Data Presented at ASCO Show Improved Complete Response with Jemperli as a First-Line Treatment for Locally Advanced Rectal Cancer in Patients with Mismatch Repair Deficient Status

Image Credit: Adobe Stock Images/Julien Tromeur

Updated results from the Phase II collaborative study of Jemperli (dostarlimab) show the promise of the medication as a treatment for mismatch repair deficient (dMMR) locally advanced rectal cancer in offering an alternative to surgery, according to GSK. The trial, performed in partnership with Memorial Sloan Kettering Cancer Center (MSK), found that Jemperli produced a 100% clinical complete response (cCR) in participants administered the drug, according to data presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting.¹

“The data showing no evidence of disease in 42 patients is remarkable. These results bring us one step closer to understanding the potential of dostarlimab in this curative-intent setting for patients with dMMR locally advanced rectal cancer,” said Hesham Abdullah, SVP, Global Head Oncology, R&D, GSK, in a press release. “We look forward to evaluating dostarlimab in certain colorectal cancers in our ongoing AZUR-1 and AZUR-2 registrational studies.”

Jemperli is a programmed death receptor-1 (PD-1)-blocking antibody that binds to the PD-1 receptor and blocks its interaction with the PD-1 ligands PD-L1 and PD-L2. It has shown potential both as a monotherapy and in combination with standard of care and future novel cancer therapies, particularly in patients with currently limited treatment options.

The trial included 42 patients who completed treatment with Jemperli, with complete pathologic response or no evidence of tumors present. Additionally, the first 24 patients evaluated were observed with a median follow up of 26.3 months, demonstrating a sustained cCR rate. GSK reported that safety and tolerability of the treatment remained consistent with its previously known safety profile, with no grade three or higher adverse events reported.

Currently, standard-of-care (SoC) for patients with dMMR/microsatellite instability-high (MSI-H) locally advanced rectal cancer includes chemotherapy, radiation, and eventual surgery to remove tumors. Currently, Jemperli has not been approved in any location as a treatment for locally advanced dMMR rectal cancer.¹

According to the American Cancer Society, there have been an estimated 46,220 new cases of rectal cancer this year. Overall, colorectal cancer is the second most common cause of cancer deaths for men and women in the United States combined. However, death rates have been dropping consistently over multiple decades due to colorectal polyps being found and removed more consistently before they can develop into cancers.²

“These findings demonstrate the potential of dostarlimab as a novel approach to treating locally advanced dMMR rectal cancer that leads to durable complete tumour regression without the need for life-altering treatment. As a clinician, I’ve seen firsthand the debilitating impact of standard treatment of dMMR rectal cancer and am thrilled about the potential of dostarlimab in these patients,” said Andrea Cercek, MD, Section Head, Colorectal Cancer, co-director, Center for Young Onset Colorectal and Gastrointestinal Cancer, MSK, principal investigator of the Phase II study, in a press release.

References

1. Jemperli (dostarlimab) trial continues to show unprecedented results with no evidence of disease in 100% of patients with locally advanced mismatch repair deficient (dMMR) rectal cancer. GSK. June 3, 2024. Accessed June 3, 2024. https://www.gsk.com/en-gb/media/press-releases/jemperli-dostarlimab-trial-continues-to-show-unprecedented-results/

2. Key Statistics for Colorectal Cancer. American Cancer Society. Accessed June 3, 2024. https://www.cancer.org/cancer/types/colon-rectal-cancer/about/key-statistics.html#:~:text=The%20American%20Cancer%20Society's%20estimates,men%20and%2018%2C890%20in%20women)