Sanofi, Janssen to Collaborate on Extraintestinal Pathogenic E. Coli Vaccine

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Sanofi announced in a company press release that it has agreed to terms with Janssen, a Johnson & Johnson company, to develop and commercialize a vaccine candidate for extraintestinal pathogenic E. coli (9-valent), currently in Phase III of clinical trials at Janssen. As per the deal, the two organizations will co-fund current and future research and development costs. Sanofi will provide an upfront payment of $175M Janssen, followed by development and commercial milestones.

“E. coli is a significant cause of sepsis, mortality, and antimicrobial resistance in older adults, and the number of cases is rising as the population ages,” said Thomas Triomphe, EVP, vaccines, Sanofi. “In line with our commitment to design and deliver first- or best-in-class medicines and vaccines, this agreement with Janssen aims to positively impact public health by reducing hospitalization costs and the burden on health systems associated with ExPEC and help older adults around the world to live longer, healthier lives.”

Reference: Press Release: Sanofi announces agreement for potential first-in-class vaccine against extraintestinal pathogenic E. coli. Sanofi. October 3, 2023. Accessed October 3, 2023. https://www.sanofi.com/en/media-room/press-releases/2023/2023-10-03-05-30-00-2753274