The Stories That Shine

Meg Rivers
Managing Editor
Pharmaceutical Executive

That isn’t any less true for Lisa LeCointe-Cephas, SVP, chief ethics and compliance officer and office of general counsel, human health, Merck. In this issue, our executive profile, written by Lisa Henderson, features LeCointe-Cephas. Prior to working in pharma, LeCointe-Cephas set out to be a doctor and pivoted to become a lawyer due to her interest in people and what makes them tick. She worked in securities litigation and white-collar criminal defense, specifically for Kirkland & Ellis LLP. As you can imagine, her experiences there impacted how she approaches leadership in her work at Merck, specifically about how to communicate effectively. She also emphasized the importance of not focusing on negative thoughts when you “fail” and make mistakes but instead focusing on how to do things better next time. She also adopted a stop-drop-roll mantra, which I found really interesting and unique. But I won’t spoil that one for you.

Also in this month’s issue is our annual Product Launch coverage. We feature five drugs that our editorial board and team thought were especially impactful in the industry and to the lives of patients:

• Camzyos (mavacamten): For adults with symptomatic obstructive hypertrophic cardiomyopathy (obstructive HCM). (Bristol Myers Squibb)
• Enhertu (fam-trastuzumab - deruxtecan-nxki): For adults who have human epidermal growth factor receptor 2 (HER2)-positive breast cancer that cannot be removed by surgery or that spread to other parts of the body. Patients have had prior anti-HER2 breast cancer treatment for metastatic disease or have breast cancer that has come back during or within six months of finishing treatment for early-stage breast cancer. There are additional indications on the Enhertu website. (Daiichi Sankyo and AstraZeneca)
• Rebyota (fecal microbiota, live-jslm): For adults for the prevention of recurrence of Clostridioides difficile infection (CDI) following antibiotic treatment for recurrent CDI. (Ferring Pharmaceuticals)
• Sunlenca (lenacapavir): For adults, used alongside other human immunodeficiency virus-1 (HIV-1) medicines to treat HIV-1 infection in patients who 1) have received HIV-1 medicines in the past, 2) have an HIV-1 virus resistant to HIV-1 medicines, and 3) whose current HIV-1 treatments aren’t working for them. (Gilead Sciences)
• Tzield (teplizumab-mzwv) injection: For adults and pediatric patients with stage 2 type 1 diabetes (T1D). It’s a CD3-directed monoclonal antibody indicated to delay the onset of stage 3 T1D. (Provention Bio, a Sanofi company)

Thank you to everyone who contributed insights, articles, and time to this issue. Without you all, we couldn’t do what we do!