Recruiting patients remains one of the most difficult challenges clinical trial sponsors face. Recognizing that fewer than five percent of eligible adult patients enroll in therapeutic trials.
Recruiting patients remains one of the most difficult challenges clinical trial sponsors face. Recognizing that fewer than five percent of eligible adult patients enroll in therapeutic trials, many sponsors have turned to supplemental recruitment, the practice of pre-qualifying community-based patients for referral to clinical trial sites for screening.
“The primary reason that patients do not participate is that they are unaware of opportunities to do so,” said Elisa Cascade, MBA, Vice President of Corporate Development at DrugDev.org, an online network designed to link trial sponsors and investigators. “Physician investigator sites and other researches are actively seeking opportunities to make community-based patients aware of clinical trials. There was little information in the literature on patient-level interest in studies and patient characteristics associated with study interest.”
Ms. Cascade was lead author on a survey of nearly 8,600 patients that focused on drivers of patient interest in clinical trial participation. The study was conducted by Quintiles, where she was Vice President, Digital Patient Unit. The survey identified three key variables that explain patient interest in studies, age, condition, and treatment satisfaction.
“These findings have important implications for the clinical trial recruitment plan,” Ms. Cascade said. “Investigators who tailor their recruitment strategies to patients who are younger and have a greater dissatisfaction witdh their current treatment (due to bothersome side effects or unmet treatment need) should see a better return on investment for their patient outreach activities.”
This article is part of a series examining popular peer-reviewed articles from years past called “Peer-Reviews Revisited: Why You Should Read Today.” You can read the other articles in the series here.
Beyond the Birthrate: The Societal Costs of Maternal Mortality
September 6th 2024Head of Medical Affairs and Outcomes Research at Organon, Charlotte Owens, MD, FACOG, discusses the most critical changes needed to close the gaps in R&D for maternal health solutions and how feasible they are to make.
Efsitora Demonstrates Non-Inferiority vs. Insulin Glargine, Degludec for Type 2 Diabetes
September 5th 2024Results from the QWINT-1 and QWINT-3 trials found that insulin-naïve patients achieved similar reductions in A1C levels using once-weekly efsitora compared to daily insulin glargine and degludec.