
Toragen CEO Sandra Coufal, MD, discusses why the company is targeting HPV’s overlooked E5 protein, positioning its small-molecule therapy as a potential complement to checkpoint inhibitors like Keytruda across HPV-driven cancers.
Dr. Sandra Coufal has over 30 years of experience as a physician and serial entrepreneur working with multiple successful companies in medicine, chemistry, biotechnology, material sciences, and digital technology.
Dr. Coufal served as Biomedical Advisor for the Genomics Institute of the Novartis Research Foundation for 21 years where she vetted drug development projects and provided senior-level advice.
Currently, Dr. Coufal serves on the Board of Directors of BioAesthetics, Inc. and personally co-led their Series A financing round of $5mm in 2020. Additionally, Dr. Coufal serves on both the Industry Advisory Board of the Harper Cancer Research Institute at the University of Notre Dame and the New Orleans BioFund.
Dr. Coufal received her medical degree from the University of Texas, Southwestern Medical School at Dallas. Previously, Dr. Coufal was Head of the Division of Internal Medicine at the Torrey Pines site of Scripps Clinic in La Jolla, CA, where she also sat on the Board of Scripps Green Hospital as the Representative-at-Large. She also completed an internship and residency in Internal Medicine at the University of Texas Southwestern Medical School at Dallas under Chairman Dr. Daniel Foster. She received her Bachelor of Science undergraduate degree from the University of Notre Dame and was designated a Notre Dame Scholar.

Toragen CEO Sandra Coufal, MD, discusses why the company is targeting HPV’s overlooked E5 protein, positioning its small-molecule therapy as a potential complement to checkpoint inhibitors like Keytruda across HPV-driven cancers.

Sandra Coufal, MD, CEO of Toragen, says the company is positioning its HPV E5 inhibitor TGN-S15 not as a competitor to Merck’s Keytruda, but as a combination partner designed to enhance checkpoint inhibition.

Sandra Coufal, MD, CEO of Toragen, explains how the company’s Scientific Advisory Board was built to provide highly specialized expertise around HPV biology, immuno-oncology, and clinical development as TGN-S15 advances through trials.

Toragen’s partnership with the Bill & Melinda Gates Foundation highlights how global health priorities and commercial biotech strategy can align around one of the world’s deadliest HPV-driven cancers.

Toragen CEO, Sandra Coufal, MD, says women’s health remains structurally underfunded, arguing that outdated market assumptions continue to undervalue the true commercial opportunity in HPV-driven cancers.

Toragen CEO Sandra Coufal, MD, explains why the overlooked HPV E5 protein may represent a breakthrough therapeutic target after decades of failed attempts against traditional viral pathways.

May 14th 2026

May 15th 2026